Loading...
 
Toggle Health Problems and D

Viral respiratory infections reduced by both Vitamin D and Zinc – meta-analysis -Oct 2021

Nutrient supplementation for prevention of viral respiratory tract infections
in healthy subjects: a systematic review and meta-analysis

Allergy. 2021 Oct 9. doi: 10.1111/all.15136
Berber Vlieg-Boerstra 1, Nicolette de Jong 2 3, Rosan Meyer 4, Carlo Agostoni 5 6, Valentina De Cosmi 5 6, Kate Grimshaw 7, Gregorio Paolo Milani 5 6, Antonella Muraro 8, Hanneke Oude Elberink 9, Isabella Pali-Schöll 10 11, Caroline Roduit 12 13 14, Mari Sasaki 15, Isabel Skypala 16, Milena Solokowska 17, Marloes van Splunter 2, Eva Untersmayr 11, Carina Venter 18, Liam O'Mahony 19, Bright I Nwaru 20

It remains uncertain as to whether nutrient supplementation for the general population considered healthy could be useful in the prevention of RTIs, such as COVID-19. In this systematic review and meta-analysis the evidence was evaluated for primary prevention of any viral respiratory tract infection (RTI) such as SARS-CoV-2, through supplementation of nutrients with a recognized role in immune function: multiple micronutrients, vitamin A, folic acid, vitamin B12, C, D, E, beta-carotene, zinc, iron and long chain polyunsaturated fatty acids.
The search produced 15,163 records of which 93 papers (based on 115 studies) met the inclusion criteria, resulting in 199,055 subjects (191,636 children and 7,419 adults) from 37 countries.
Sixty-three studies were included in the meta-analyses, which was performed for children and adults separately.
By stratifying the meta-analysis by world regions, only studies performed in Asia showed a significant, but
heterogeneous protective effect of zinc supplementation on RTIs (RR 0.86, 95%CI 0.7-0.96, I2=79.1%, p=0.000).
Vitamin D supplementation in adults significantly decreased the incidence of RTI

  • (RR 0.89, 95%CI 0.79-0.99, p=0.272), particularly in
  • North America (RR 0.82 95%CI 0.68-0.97),
  • but not in Europe or Oceania.

Supplementation of nutrients in the general population has either no, or at most a very limited effect on prevention of RTIs. Zinc supplementation appears protective for children in Asia, while vitamin D may protect adults in the USA and Canada. In 10/115 (8.7%) studies post-hoc analyses based on stratification for nutritional status was performed. In only one study zinc supplementation was found to be more effective in children with low zinc serum as compared to children with normal zinc serum levels.
 Download the PDF from VitaminDWiki

VitaminDWiki

Items in both categories Breathing and Zinc:

Items in both categories Breathing and Meta-analysis:

Items in both categories Breathing and Virus:

VitaminDWiki pages containing RESPIRATORY or RTI in title (76 as of Oct 2021)

This list is automatcially updated

Items found: 91
Title Modified
Infant respiratory distress reduced by Vitamin D – meta-analysis July 2024 03 Aug, 2024
2X less risk of respiratory distress syndrome if 50,000 IU of Vitamin D just before premature birth – RCT May 2024 18 May, 2024
40 cents of Vitamin D given once during pregnancy reduced respiratory problems by 3% – May 2023 28 Feb, 2024
COVID Vaccinated Children 1.25 X More Likely to Be Hospitalized for Respiratory Illness - CDC Jan 2024 12 Jan, 2024
Off Topic: Xylitol reduces cavities, preterm births, osteoporosis, RTI, obesity, diabetes, etc. - several studies 01 Jan, 2024
Respiratory infection, children and Vitamin D - many studies 08 Oct, 2023
Acute respiratory tract infections not reduced by Vitamin D if already have a good level – Jan 2021 30 Sep, 2023
Respiratory infections in children 6 X more likely if low Vitamin D (avg of 2 studies) - Aug 2023 22 Aug, 2023
Respiratory infections reduced by 63 percent with 4000 IU vitamin D daily - RCT Dec 2012 17 Jul, 2023
3% fewer respiratory problems in children if single 100K vitamin D in 3rd trimester – May 2023 27 May, 2023
Cost-effective to give Vitamin D to all children to prevent acute respiratory infection – April 2023 09 Apr, 2023
The vitamins and minerals that help the immune system respond to respiratory viruses – Dec 2022 06 Dec, 2022
Respiratory viral infection (RSV) and low vitamin D - many studies 18 Nov, 2022
Cod liver oil does not prevent Respiratory Infections (no surprise, only 400 IU of vitamin D) RCT – Sept 2022 08 Sep, 2022
Calcifediol (semi-activated Vitamin D) might treat Respiratory Diseases such as COVID - July 2022 19 Jul, 2022
2.4 X fewer lower respiratory track infections in infants getting 400 IU of Vitamin D – May 2022 24 May, 2022
Vitamin D reduces RTI, Omega-3 reduces wheezing or asthma – March 2022 11 Apr, 2022
Small doses of vitamin D do not reduce risk of Acute Respiratory Infection - meta-analysis Feb 2022 15 Feb, 2022
Vitamin D and infectious diseases like RTI, TB and Sepsis – Nov 2014 16 Jan, 2022
Viral respiratory infections reduced by both Vitamin D and Zinc – meta-analysis -Oct 2021 11 Oct, 2021
Acute viral respiratory infections (RTI) reduced by Vitamin D - 20 reviews - Aug 2020 24 Sep, 2021
Respiratory Tract Infections during cold weather – similar rates for low and very low vitamin D – Sept 2021 24 Sep, 2021
Infant Respiratory Infections not reduced by mothers taking small amount of vitamin D (28,000 weekly)– RCT July 2021 03 Jul, 2021
Vitamin D may reduce Respiratory Tract Infections and the use of antibiotics – March 2021 24 Jun, 2021
Vitamin D reduces Respiratory Tract Infections and reduces use of antibiotics – March 2021 15 Apr, 2021
Recurrent RTI treatment success: Conventional 71 pcnt, Vitamin D 96 pcnt – March 2021 12 Apr, 2021
Small vitamin D doses provide small benefits for acute respiratory infections – Meta-analysis March 2021 31 Mar, 2021
Vitamin D reduces viral respiratory infections – editorial April 18, 2020 02 Mar, 2021
Respiratory Tract Infection risk reduced 2X by Vitamin D loading doses – meta-analysis Jan 2021 22 Jan, 2021
400 IU Vitamin D for UK adults with COVID is based on a RTI study biased by infants - Jan 2021 29 Dec, 2020
Preemie Respiratory Distress Syndrome is 5X more likely if low vitamin D – Dec 2020 18 Dec, 2020
Upper Respiratory Tract Infections in adults reduced by just 400 IU of vitamin D – RCT Dec 2020 12 Dec, 2020
Respiratory deaths in seniors – 40 percent are attributable to low vitamin D – Aug 2020 18 Aug, 2020
Respiratory problems in Children 1.4X more likely if poor Vitamin D receptor – April 2020 22 Jul, 2020
Reasons why some Respiratory Allergy studies find that Vitamin D does not help much – June 2020 21 Jun, 2020
Zinc, respiratory tract infections and COVID-19 – July 2020 07 Jun, 2020
Lower Respiratory Tract Infection in Infants reduced 5.9 X by daily 600 IU of vitamin D (China) - March 2020 07 Mar, 2020
Four of the 7 types of human Coronavirus only cause mild respiratory infections 04 Feb, 2020
Respiratory Disease exacerbations (Asthma, CF, COPD) may be treated by Vitamin D – July 2019 26 Nov, 2019
No preemie had even 30 ng of vitamin D, lower D associated with more Respiratory Distress – Aug 2013 24 Jul, 2019
Acute respiratory distress – 100 percent of patients were vitamin D deficient– April 2015 09 Jun, 2019
Upper respiratory infection associated with poor Vitamin D Receptor – Oct 2018 16 Feb, 2019
Respiratory Distress Syndrome in preemies 5 X more likely if poor vitamin D receptor – Feb 2019 15 Feb, 2019
Respiratory infections reduced only 20 percent by Vitamin D (ignored dose size, duration, type, etc) – meta-analysis Jan 2019 25 Jan, 2019
Upper respiratory infection 15 percent more likely if poor Vitamin D receptor– Oct 2018 09 Dec, 2018
Low vitamin D at ICU admission is associated with cancer, infections, acute respiratory insufficiency and liver failure – Oct 2018 27 Oct, 2018
Respiratory Virus risk reduced 35 percent by Vitamin D (14,000 IU weekly) – RCT Oct 2018 18 Oct, 2018
Respiratory disase rate increase 3X after remove tonsils - June 2018 08 Jul, 2018
Respiratory tract microbiome and breathing problems 18 Jun, 2018
Childhood Respiratory Health hardly improved with 600 IU of vitamin D (need much more) – May 2018 28 May, 2018
Pollutants increase Respiratory problems, Vitamin D, Omega-3, etc. decrease them – May 2018 05 May, 2018
Respiratory Tract Infections in children 7.4 X more likely if poor Vitamin D Receptor – 2008 11 Feb, 2018
Influenza risk reduced 2X by 2,000 IU of Vitamin D (vs 400), RTI reduced 3X by 400 or more IU – July 2017 23 Jan, 2018
Review of meta-analyses of non-skeletal benefits of vitamin D (Mortality, RTI, etc) – July 2017 28 Nov, 2017
Preemies with poor lungs (Respiratory distress syndrome) have low levels of vitamin D – Nov 2017 14 Nov, 2017
Respiratory infection in infant was 7 X more likely if low cord Vitamin D – March 2017 28 Sep, 2017
Acute respiratory tract infections prevented by vitamin D (even when ignoring the dose size – Meta-analysis Feb 2017 09 Aug, 2017
RTI – Feel much better if increase vitamin D level above 40 ng (4000 IU) – RCT Sept 2015 18 Jul, 2017
Vitamin D in respiratory diseases – Spring 2017 09 Apr, 2017
The relationship between Vitamin D and the respiratory system remains inconclusive – Jan 2016 06 Mar, 2017
Fewer respiratory infections if optimal level of vitamin D (more than 47 ng) – Sept 2013 03 Mar, 2017
Vitamin D effects on lung immunity and respiratory diseases – 2011 29 Jan, 2017
Respiratory tract infection eliminated in 36 percent of people by 4000 IU of Vitamin D – RCT Sept 2015 13 Jan, 2017
Monthly 100,000 IU of vitamin D decreased respiratory infection but increased falls – Nov 2016 10 Dec, 2016
Acute Lower Respiratory Infections in Children - associated with low vitamin D – meta-analysis Dec 2014 16 Sep, 2016
Immune response to respiratory viruses – vitamin D connection – review May 2015 17 May, 2016
Lower respiratory tract infections in children associated with Low Vitamin D – meta-analysis May 2016 15 May, 2016
Acute respiratory infection treated by vitamin D in 6 of 12 clinical trials – review Nov 2012 15 May, 2016
Respiratory tract infections in childhood – vitamin D is needed, no consensus of how much – Oct 2015 15 May, 2016
Acute respiratory infection worsened by too infrequent vitamin D supplementation – RCT June 2015 17 Dec, 2015
Respiratory diseases helped by vitamin D if initially have low level – RCT review Jan 2015 13 Oct, 2015
Respiratory distress after preterm birth is more likely if low vitamin D – review April 2015 05 Aug, 2015
Respiratory infections (RTI) cut in half by 20,000 IU weekly vitamin D if initially deficient – RCT March 2015 18 Apr, 2015
Respiratory Infection associated with vitamin D less than 40 ng – March 2015 18 Apr, 2015
Low dose Vitamin D during pregnancy and infancy results in strange acute respiratory infection response – April 2015 24 Mar, 2015
Vitamin D and Respiratory Tract Infections – meta-analysis with charts June 2013 24 Mar, 2015
Acute lower respiratory infection 5X more frequent with low vitamin D intake – June 2012 20 Mar, 2015
Newborn acute lower respiratory tract infection associated with low maternal vitamin D – March 2015 20 Mar, 2015
Reduced viral respiratory tract infections by half by having more than 38 ng of vitamin D – June 2010 29 Oct, 2014
Acute Lower Respiratory Infections in Children: 13 of 18 studies found associations with low vitamin D – meta-analysis Dec 2014 23 Oct, 2014
Respiratory Tract Infection visits 2.5 less likely with vitamin D: Pregnancy 2000 IU, Infant 800 IU – RCT Oct 2014 04 Oct, 2014
Far fewer lower respiratory tract infections at 36 months if good vitamin D during pregnancy – Nov 2013 18 Jul, 2014
Respiratory viral infections might be prevented by vitamin D supplementation in those with low vitamin D – Sept 2014 18 Jul, 2014
Upper respiratory tract infection 2X more likely if vitamin D less than 30 ng – Aug 2013 12 Feb, 2014
Vitamin D reduces respiratory tract infections by 40 percent– meta-analysis Dec 2012 28 Oct, 2013
Vitamin D and respiratory tract infections - Wikipedia June 2013 29 Jun, 2013
Largest cause of infant deaths is respiratory infections, which is associated with low vitamin D – April 2011 23 Jun, 2013
100 percent of Acute Respiratory Failure patients had low vitamin D - April 2012 21 Jun, 2013
Low vitamin D associated with respiratory, digestive, and other deaths – Dec 2012 04 Jan, 2013
Hypothesis: Respiratory problems will decrease with increased vitamin D – Jan 2012 02 Dec, 2012
Just 300 IU daily of vitamin D reduced respiratory infections by 50% – RCT Aug 2012 25 Aug, 2012
Created by admin. Last Modification: Monday October 11, 2021 16:11:27 GMT-0000 by admin. (Version 5)
Viral respiratory infections reduced by both Vitamin D and Zinc – meta-analysis -Oct 2021        
615 visitors, last modified 11 Oct, 2021,
Printer Friendly Follow this page for updates
Page actions
Print
Edit Files 1

Attached files

ID Name Comment Uploaded Size Downloads
16392 Viral respiratory meta_compressed.pdf admin 11 Oct, 2021 757.09 Kb 188